Should I use money from an HSA account for the first part of my medical expenses (say the first 7.5%) when I intend to deduct anything above that amount on my taxes?

If I have significant medical expenses, where I will be able to deduct an amount above the limit from my federal taxes (either 7.5% for 2020 or 10% for 2021) should I pay the first non-deductible portion with an HSA account or will that reduce the taxable amount of my medical expenses?