There are over 20 types of 1099's. I point this out, only because other's reading this may not make the same assumption that I am, and that you're talking about the 1099-S specifically. You'll report the sale in the "Sale of Home (Gain Or Loss)" in the Less Common Income section under the Personal Income tab. Note that the program will not specifically ask you for a 1099-S form. But the fact you received such a form means you have to report it, be it a gain or a loss. The aforementioned section in the program is where you'll report it.
