If you owned and used the home as your main home for at least two out the five-year period prior to the date of sale, and did not exclude another home during that two year period, then you can exclude up to $250,000 ($500,000 if married filing jointly) of gain from the sale.
See https://www.irs.gov/taxtopics/tc701
TurboTax will walk you through the process, Step-by-Step, of entering the transaction in the Sale of Home section.
You're eligible for the exclusion if you have owned and used your home as your main home for a period aggregating at least two years out of the five years prior to its date of sale. You can meet the ownership and use tests during different 2-year periods. However, you must meet both tests during the 5-year period ending on the date of the sale. Generally, you're not eligible for the exclusion if you excluded the gain from the sale of another home during the two-year period prior to the sale of your home.
