That's an interesting question. Generally speaking, you should take all deductions and credits allowed to you. If you skip taking some deductions in order to make your income look bigger (maybe you don't mind paying more tax because a bigger income will help you qualify for loans or other tax credits) that may be considered fraud.
Although it is also true that if you know you can't take the itemized deduction, you don't need to waste time entering the items. Turbotax's design philosophy is that you should enter everything and let the program decide.
