If Alabama state tax was withheld from your spouse's W-2, you will have to file a nonresident Alabama return, even if she never lived there.
In addition, if she did not work or commute to Alabama and she made her income from Florida, then the employer withheld state taxes in error. Make sure you enter 0 on the screen that asks for the income earned in Alabama. This will eliminate your tax liability for Alabama and you will get a full refund of taxes paid to Alabama.
@jbilla
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