Before you continue with a return for Ohio, you should clarify the two conflicting statement you have made regarding the self-employment income.
In your initial question you stated you received a 1099-NEC 'for work performed in Ohio'. If this is true, then you do need to file the Ohio return.
Then, in a more recent response you stated that the 1099-NEC is self-employment income 'from an Ohio source'. If the work was not performed in Ohio, but in West Virginia where you are a resident, then no Ohio return is required. You would not file an Ohio return just because the income is coming from an Ohio source.
That being said, to answer your questions if you do need to file the Ohio return, the requirement that one spouse should be a non-resident of Ohio and has no income from Ohio would apply to your situation based on the information that you shared. Also, the Married Filing Separate Federal return that was created in order to file the Married Filing Separate Ohio return should be included since it shows how the numbers on the Ohio return were derived.
@macck
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