Can I adjust estimated tax payments?

I know I need to make estimated tax payments this year, and will be making much less than last year, so am trying to estimate 100% tax for this year (2025). I paid equal amounts in april and june. However, we had a large capital gain in july that was unaccounted for. I went through the TT Estimated tax worksheets, and entered a new "investment" amount, and it came up with much larger payments for September and January.

 

I had thought that the estimated payments needed to be "consistent" throughout the year? Is it OK to pay smaller estimates in april and june, but then have much larger estimated tax payments in september and january? Will this trigger a penalty?

 

If it does, how else can this be remedied?