RMD will be large can I pay the tax liability on the amount from the proceeds before 12/31/25

I just learned my RMD on my IRA will be close to 100k for 2025.

Can I pay the tax obligation, which will be over 30k, via IRS Direct when I sell the 100k worth of stock shares to avoid a penalty for not having had the taxes withheld by my brokerage company?

Thanks for your advice