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After you file
@ Rs6er
ADDENDUM:
If you have already filed your 2021 return, then when you go back into it to figure the 2022 estimated taxes, do not make changes in your actual already-filed return. i.e., do not experiment using the actual return. It's OK to use that W-4 and Estimated Tax section, since it does not affect the return itself.
If you later have to amend the return, it must start off exactly as you originally filed it using the formal amending process.
If you do want to experiment any, some people make a second copy of their *.tax2021 data file, label it something distinctive like "TrialCopy2021return", and then use that copy to try things. The 2021 desktop software also has a worksheet in Forms Mode called "What-If Worksheet", where some people try various scenarios.