Turbo Tax and any other tax program calculates the quarterly payments based on the prior year activity. Paying that would avoid penalties (depending on income level, may pay 110% of prior year tax)
If you would like to be more accurate and if your income will be significantly different from the prior year, then you would need to keep track of your books (if your income is business related which I assume is the case.) You would make estimated payments based on the projections. Then you can create mock returns in TurboTax seeing what it calculates the tax to be.
