You should file your 2020 return in a timely manner, whether or not you hear back from the IRS by April 15th (or whatever date the due date turns out to be).
The processing of returns from year to year is largely independent - the IRS will expect you to file your 2020 return even if your 2019 CP05A is not resolved.
I suppose you have seen this, but here is the IRS page on the CP05A.
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