When you choose to apply your refund to next year's taxes, the IRS will apply your refund to the first installment(s) of estimated taxes until all your refund has been used. And TurboTax used the same rule to calculate the amount of estimated tax you have to pay for each installment.
In your case, it appears that your applied refund was larger than 1/4 of your total estimated tax for 2021. So the refund was used for your first installment, then the remainder of that refund is applied to the second installment which is be smaller than 1/4 of the total.
This is why you have no voucher for the first payment, a voucher for a reduced amount for the second payment and two equal vouchers (for 1/4 of the total estimated taxes) for the 3rd and 4th payment.
You do not have to worry about missing the first payment. Applying your refund to next year's taxes and paying the vouchers as printed out will be exactly like receiving refund and paying the 4 estimated payments.
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