You really should seek a consultation with local legal counsel. You will need to have a quitclaim deed prepared and properly recorded in any event and any lienholder(s) (e.g., mortgage lender(s)) may need to be contacted.
https://www.avvo.com/real-estate-lawyer.html
There should be no federal income tax (or gift tax) consequences with respect to a title transfer to your wife, but there are other issues that should be taken into consideration.
One issue might be an individual's financial condition. Attempts, for example, to make a party judgment proof rarely work out well nor do attempts to evade future creditors (both of which may come within the purview of the fraudulent conveyances act).
