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Thanks for the reply, I should have been more clear, my marginal tax bracket is 37%. The tax I say owe is for current year 2022 as my company only withholds 22% when the RSU vests every month. I'm trying to pay taxes so that the tax bill doesn't come with a penalty. The shares I've sold ( a portion of my RSU that was vested in 2020 and 2021) is also in 2022 July and August. 

So considering that both events( less withholding of salary in 2022 as well as the capital loss from selling shares in 2022) happened in current year should I pay 2K ( difference between my withholding and capital loss) or 70K?