I'm a full-time employee and my wife is self-employed

If I am full-time employed (W-2), and my wife is self-employed, and filing jointly, does my wife need to pay quarterly withholdings, even if I withhold enough on my paycheck using W-4 to cover roughly 100% of household tax liability? What about state income tax, and Self-employed tax for my wife's income; can all be included in W-4?