Having the same issue with TT2021.
Found a solution. It might not be Turbo Tax's fault but Windows Security.
Don't turn off Controlled folder access. That might compromise your Windows security.
Here's what you do. First close your Turbo Tax app.
1. Search "Controlled Folder Access" in Windows
2. Click the link: "Allow an app through Controlled folder access"
3. Click the "+ Add an allowed app" button near the top of the app list
4. Select "Recently Blocked App"
5. Find the Turbo Tax executable
6. Try to save your tax file again.
Hope this helps some of you.
