I'm a non-expert, except that I have been filing my own returns for about 60 years.
Tax for 2021 and first of four estimated payments for 2022 are due by April 18(? something like that). I pay those two with separate checks, and send each separately. Actually, since you are asking the question of Turbotax, suggest you e-file the 2021 amount, and send a check for the first estimated payment for 2022. Send it out the same day you e-file so you don't forget! And I send the additional three estimated payments when each is due.
