Generally yes. There are a handful of professions which the IRS allows to use a residence other than your home.
A good example would be the airline industry, where crew members are domiciled in a different city from which they actually live. There are several hurdles which must be met to establish residency at the crew domicile. The crewmember must spend 15 days minimum per month working out of the domicile and have a physical address there. This residency has been recognized by precedence in IRS case law. I imagine that there could be arguments for similar circumstances in industries that require workers to travel to a hub for work.
