The cost of building a garage would be a 'capital improvement' that gets added to the Cost Basis of your home.
Use the Cost Basis amount when asked for this info in the Home Office section in TurboTax. You enter your home details as Asset in this section to claim depreciation.
You can calculate the square footage of your business-related garage space and add it to the total Home Office square footage.
Click this link for detailed info on the Home Office Deduction.
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