If you say YES, the sale was included in the sale of your main home, TurboTax should ask how many months you lived there in the last 5 years, to qualify you for a partial home sale exclusion.
If you didn't start renting it until 2017, you did live in it in 2016 (this may qualify you for a partial exclusion if you have a Gain).
However, be sure you actually have a loss. If you purchased the property for 100K, depreciated 20K, the cost basis of the home is now 80K. If you sold it for 90K (less than you paid, but more than the current Cost Basis), you actually have a Gain of 10K, for example.
When you enter the sale in the Rental Section, TurboTax will calculate the Cost Basis for you to enter in the Home Sale section (look for Form 4562).
If you do have a loss, click this link for more info on Selling Rental Property at a Loss.
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