W-2 Deductions for home office

During part of 2021, I was asked by my employer to work from my home office.  The for-profit Center within the state university where I work passed an internal rule stating not more than 50% of employees in any office could be present on campus at all for any portion of the duration of the mandate.  As a result, I worked from home, met with clients virtually, and conducted all business at home by request of my employer.  This necessitated my purchasing a new desk and fixing my office up to accommodate meeting with Fortune 500 clients.  This was not part of my job description, not part of the agreed upon work location when I was hired, and my continued employment was conditional on meeting the parameters of the request.  Can I claim any of my expenses against my W-2?