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I am having this exact same problem. I spent nearly 2 hours on the phone with customer support today. They promised a resolution/update in 48 hours. I notice that some people suggest removing ALL files associated with TT21. Does that include the actual tax returns that I have almost completed?  I really hope not. I have removed TT21 software (not the 2021 returns that are still saved) and re-installed, I've updated the Mac O/S. I still can't open TT21. 

It seems like this should be a HUGE issue for Intuit.