It is normal to receive the W-2 if you sold RSUs in 2021. You should enter the W-2 and once you receive the 1099-B from E-trade, you will enter that as Employer Stock sales in the Investment Income section.
Since stock you receive through stock grants and RSUs is essentially compensation, you'll usually see it reported automatically on your W-2. Typically, taxes are withheld to go against what you might owe when you do your taxes. As with all withholding, the taxes your employer deducts from your paycheck may not be enough to cover the full amount of tax you owe when you file your return.
For more info, see How to Report RSUs or Stock Grants on Your Tax Return
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