Refund Decreased Significantly when I Reopened TurboTax

When I closed TurboTax (downloaded version) on my PC last week, my refund was around $2600 (similar to last year's). When I reopened it yesterday, it was $69. 

 

After checking many numbers, I started a new return from scratch, just to see if there were a glitch. Just by entering our two W-2s (not entering anything else), it showed a refund of $333, when it had been close to $3000 after entering the same items last week.  Could there be a glitch?