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In this specific case, there is definitely a change in tax based on the classification of this specific item in Box 14.

 

For ORR STT WAGE, if you accidentally put in "Oregon Statewide Transit Tax," it drop your federal tax by several hundred $ erroneously.  Also, it then lists this # as the amount of tax paid to the state, which is ~100% of your box 1 W-2 .  Both would be wrong.