You are correct that last year's software (for tax year 2020) did take the $300 or $150 cash charitable contribution into account. Note, however, that this change was made in late January because Congress was constantly moving the goal posts on all sorts of tax issues. In fact, the IRS updated the instructions to explain this in January, after filing has started.
At the moment, form 2210 is scheduled to be released on March 17, 2022. When the forms are updated and released, then I would expect issues like this to be updated. Since this was such a late change last tax season, I would expect that this issue will be carefully reviewed this year before the form is released.
There are many such issues being asked about here early in the tax season. Check the availability of the federal forms when asking questions, because it is likely that many of these issues will be resolved when the form (and its accompanying software) is finally released for use.
@Newk120
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