It may indeed qualify for a special exception. In Publication 523, they allow for a pro-rated exclusion if "The home became significantly less suitable as a main home for you and your family for a specific reason" that was not anticipated at the time of purchase. I'm not sure whether TurboTax will support these special exclusions, and if not, you will have to have your taxes prepared for you. But if you can exclude most of your gain, that would be worth it.
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Nick K, EA
