Q. Will the fact that my employment is 1099 change this for 2021?
A. Yes and no. No; as long as you meet the limits shown above, no underpayment penalty will be due. Yes, in that you will owe Self Employment Tax (SET) in addition to income tax. "SET" is how the self employed (anybody getting a 1099-NEC is considered self employed) pay their social security and medicare tax.
Your wife can increase her W-2 withholding at work, instead of you making quarterly payments. Since you're filing a joint return, her withholding applies to your combined tax liability.
