Same problem here with Home and Business version. I have been working on my return on and off since February. I just today let Turbotax perform an update, and now I'm getting the "looks like your tax file is corrupt, we're having trouble opening your return" message. This thread gives me the impression that this is neither an isolated nor "solved" issue.
Update: I worked with customer service and uninstalled/re-installed turbotax, which did not help. I then tried to repair the installation, but the repair process fails with an error code every time. Based on my experience plus a lot of other responses in this thread, It sure seems like the update caused the problem.
