Quarterly Taxes from IRA Inheritance

I am married filing jointly. My spouse recently received an inheritance from a traditional IRA that has been completely liquidated (not sure if that's the right terminology). She simply received a check from another family member who was handling the split of assets. How do I submit quarterly estimated taxes for this? Is this money subject to self-employment tax?

 

We both are employed and normally receive W-2 forms each year (with normal withholding, etc.). Neither of us have ever filed quarterly estimated taxes.