When you file separately from your spouse, you must both use the same method, either Itemized Deductions OR use the Standard Deduction.
Since you indicated that your spouse could be claimed as a dependent, you have indicated that your spouse will/can only use the standard deduction. Dependents cannot itemize.
Whether your spouse files a tax return is immaterial. Because he or she is a dependent, you must both use the Standard Deduction.
IRS Topic 551
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