How much should I pay in quarterly estimated taxes for Federal?

I am an independent contractor getting paid on a 1099-NEC.  20% of my yearly income? What about the deductions I can claim like my car and other misc expenses I have?  Does anything change if I file jointly with my wife and she gets paid by W2?  I did not pay any quarterly estimated taxes in 2020 and it seems that we owe a lot more this year.  Any suggestions as to what I can do when paying taxes next year so we won't get hit by a bigger tax bill?