Report the sale in the Stocks, Mutual Funds, Bonds and Other interview under Federal > Income and Expenses > Investment Income.
"Real estate" is an "Other" type of investment. When the program asks if you received a Form 1099-B, select "No". Completing the interview will generate Form 8949 and Schedule D.
See Where do I enter the sale of a second home, an inherited home, or land on my 2019 taxes? for instructions on how to access this interview in either online or desktop versions of the program.
