Should the 2021 1040-ES Payment Vouchers that printed out with my tax return, be paid each quarter even though taxes are still being withheld from our paychecks?

I have a refund coming from 2020 but 4 payment vouchers where provided by TurboTax for 2021. Is this how much taxes will be going up in 2021 that I need to pay these in addition to what is withheld from our paychecks?