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Exact same problem here using Turbo Tax Home and Business 2020.  I prepare & e-file 5 returns annually for my family and myself. I have one tax return that I was unable to transfer data from 2019 tax file (not a pdf). So I entered it manually, saved it, and closed the file. When trying to reopen the tax file, I get this message:  "Looks like your tax file is corrupt, we're having trouble opening your return. Try opening again. If that doesn't solve the problem, create a new tax return."  Trying to reopen the file never works. I have recreated it 3 times now and keep getting the same error message when trying the reopen the file. I finally e-filed the federal on the 3rd creation, saved, and closed the file.  Now I need to check the status of the return and mail the state, but I cannot reopen the file. I have tried all the trouble shooting options I can find on this website and on the internet. NOTHING WORKS!!!!!!  I have been a loyal Turbo Tax customer since 2005 and never encountered anything like this in the past.  This has been a waste of time and money. I'm seriously looking at other options for next year.