Yes, you have the choice of Self-employed (online) and Home and Business (download). Either will give you access to Form 1040-ES.
What do you mean by calculate deductions? If your expense is 100%, you would total that particular expense for the year and enter it under its proper category. If it is prorated personal and business, then yes, TurboTax can help with that calculation.
Yes, the program will help determine your estimated payments. Estimated payments
