It depends on when the debt originated.
If you owe the IRS due to debts from before the marriage, then you and your spouse should file as married filing separately. This keeps your tax situations separate and protects your spouse's finances. If you filed jointly and filed the injured spouse form, that would also protect your spouse somewhat, but not as effectively.
If you owe the IRS due to debts from during your marriage when you filed separate returns, you should continue to file separate returns.
If you owe debts to the IRS from during the marriage and you filed a joint return, then the debts are joint and there is nothing you can do to prevent the IRS from taking your spouse's refund. On a joint debt, the IRS can take the money from whichever spouse it is easier to collect from.
