You will need to mail in your return. If you are filing Married Filing Separately and your spouse has no ITIN or SS number, it is not possible to e-file.
If you are unable to get a Social Security number or ITIN for your spouse, you will need to enter a fake number in the Taxpayer Identification Number (TIN) box and then print out and mail the return. You will need to whiteout the fake number you entered, replacing that with the letters NRA in the TIN box.
You can elect to file Married Filing Jointly if you wish. Your spouse's worldwide income would be subject to US taxation.
There is an excellent page of information from the IRS here. There is more information about Taxpayer Identification Numbers (like SS and ITIN numbers) here.
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