Yes, you still need to pay taxes during the year as your revenue comes in.
You use the form 1040-ES to make the payments.
You pay more or less quarterly (but the IRS has a funny idea of what those dates are, so read the instructions at that link).
More or less, you need to have paid the tax for the year by January 15 of the next year. You may want to create a test return to make a guesstimate on how much your taxes will be.
It will be easier after the first year.
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