I was having an issue where it wouldn't transmit because it said there was an update available. It wouldn't rest, even though I would toggle the updates.
I finally closed TurboTax, did a disk cleanup and restarted my computer. Then, when I opened TurboTax, it did the normal check for updates before taking me to the saved files. I was then able to transmit my Federal return without any issues. Hope this helps.
