If the deceased person was married, the surviving spouse can file and sign the return.
An estate executor or a personal representative, who is often a relative of the deceased, can also sign the tax return.
So can an attorney, or any other person who's primarily responsible for handling the deceased's financial affairs.
See page 4 of this IRS link: https://www.irs.gov/pub/irs-pdf/p559.pdf
" If a personal representative has
been appointed, that person must sign the return.
If it is a joint return, the surviving spouse
must also sign it. If no personal representative
has been appointed, the surviving spouse (on a
joint return) signs the return and writes in the
signature area “Filing as surviving spouse.” If no
personal representative has been appointed
and if there is no surviving spouse, the person
in charge of the decedent's property must sign the return as the personal representative."
You can complete a decendent's final return using TurboTax, and you will be directed how to prepare and sign it.
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