Get your taxes done using TurboTax

The Home and Business product IS for the self-employed.    It is the top desktop edition and has the most help and guidance for the self-employed (sole proprietors, independent contractors, single-member LLC, etc.)

As I said above, the Home and Business Edition is a better product than the online Self-Employed.   It does everything online Self-Employed can do and more.  It also includes a state program as part of the purchase.  (there is a 24.99 fee to efile a state return--except no fee for New York state.  Also no fee to print and mail the state return.)  

Home and Business has the popular feature Forms Mode which can be very handy if you have to view/edit something on one of the forms.

You asked:
"One of these also does your quarterly sales tax filing if I am not mistaken?"

I haven't heard anything about that.  I don't think either of those 2 products would do that for a state.  I'm just a fellow user though.