Well then the thing to do is to report the 1st sale as a plain-vanilla sale using TT's default 1099-B entry form. Assuming the 1099-B is only reporting the out of pocket cost of the stock as the basis, then click on the "I'll enter additional info on my own" blue button. On the next page enter the correct basis in the "Corrected cost basis" box which is the sum of the out of pocket cost and the compensation reported on the W-2. (I"m assuming the sale was for the GROSS number of shares in the grant. If that's not the case then work out the correct basis to use as a per share figure and use that.)
Then the rest of the sales you can enter using the ISO step by step interview. Work completely through the "Stocks, Mutual Funds, Bonds" interview. You're not done when your entered the trade information. Eventually you'll come to a page that tells you the compensation TT has calculated and asking if that's the amount on your W-2. You'll say "No" and TT will include that amount on line 7 of the Form 1040.
