Self employed tax question

my wife works remotely for a university in a different state than we reside. 100% work from home. They do not provide health care or other benefits (401k, etc) as part of her consulting. We received a W-2 for this income. I would like to claim this as a self-employed business with expenses, but not sure I can since we received a W-2 from the university. How should I account for home business expenses related to this transaction?