Yes, you should make quarterly payments, called estimated tax payments. You can figure out (estimate) how much to pay in TurboTax Self-Employed, by going to the Personal Tab, then choosing Other Tax Situations, then scrolling down to Other Tax Forms and choosing Form W-4 and estimated taxes. You don't want to work on a W-4, but you do want to work on estimated taxes. It takes a little time to enter this information, so be patient. You can then print out 4 Forms 1040-ES to make quarterly payments. You can also make payments to the IRS electronically each quarter.
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