You must include all income from all sources on the same tax return. When you have 1099-MISC income from self employment and have expenses associated with that income, you must use the Self Employed version. If you have no expenses, you can use Deluxe or Premier. 

When using the CD/download product installed on your computer, you can use any version because they all have the same forms. The Home & Business version would provide more guidance for self employment income.