More info is needed, and someone familiar with that section for 2018 may be able to comment. Are you a recreational or professional gambler?
You need to first consider what your standard deduction is. What is your filing status--single, married filing jointly, MFS, head of household, etc.? Are you age 65 or older? And/or blind?
How much of the deduction may count may also depend on the amount of your other allowed itemized deductions. i.e., if you have a lot of other itemized deductions, then the gambling deduction would count more.
As for "how much difference", it also depends on your tax bracket. Do you have other income?
In the meantime, here is an article you can review:
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