W2 plus 1099 income for taxes (multiple jobs) and quarterly estimated taxes

I have a full time healthcare W2 job and I do extra locums work under 1099 with a different company. 

The W2 job I had for over a year and my taxes are withheld and I don't have to worry about the taxes for that part. 

The 1099 job I started in July of 2025. 

I am new to this and started researching about quarterly taxes and I had missed the September 15 deadline since it is already the end of October 2025. 

I maxed out my social security taxes earlier this year from my W2 earnings. 

I am not even sure how to calculate my estimated taxes accurately. Is it just better to overestimate and pay on the IRS website? Will there be a penalty? 

Do I pay on the IRS website and also in my state tax website? 

I am setting aside the money I would be paying in taxes and I estimate that I will owe an additional $41,600 because I will be making $116,000 from this additional 1099 job.