1099-nec and quarterly payment

My wife and I file married jointly.  Her tax situation has changed this year.  She received her last paycheck from her employer in August.  Just a few months before that she became a contractor with a different company.  When do we start figuring out the quarterly tax payments?  Do we do that now or wait until we file in 2026?  As a follow-up, if we pay quarterly tax payments can that amount be taken from my withholdings (I would update my w4)?