If you are in fact subject to an estimated tax penalty for not paying in sufficient tax throughout the year, the TurboTax program will alert you to that situation, and give you an opportunity to lower that penalty (for instance if you met any exceptions to the penalty, or if you earned the income unevenly during the year.)
TurboTax will also recommend Estimated Tax Payments on Form !040-ES if you will be in a similar situation in the current year.
For more on Estimated Taxes, see this link
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